Atopic Dermatitis is More Than Dry Skin

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Managing Your Atopic Dermatitis

Repairing the Skin Barrier is Key to Managing Your Atopic Dermatitis

Your healthcare professional has diagnosed your itchy, red, irritated skin as atopic dermatitis, a chronic condition, commonly referred to as eczema.

Moisturizing is Not Skin Barrier Repair

Typical moisturizers contain an occlusive ingredient, like petrolatum, which forms a temporary film on the surface of your skin to slow water loss. The addition of a humectant helps your skin feel better by drawing moisture from below the surface of the skin. You will need to do more than moisturize to maintain a healthy skin barrier.

Doing More with EpiCeram Skin Barrier Emulsion

Replenish the key lipids that are deficient in atopic skin and correct the pH imbalance. EpiCeram contains high levels of 3 essential lipids (ceramide, cholesterol, and free fatty acids) in the ideal ratio needed for skin barrier health. EpiCeram is formulated at a healthy pH of 5.0. Use EpiCeram to restore and repair to build a healthy skin barrier, keeping moisture in and irritants out.

Patient Resources

Have questions about EpiCeram? Contact one of our Patient Advocates at 1-888-546-2735 weekdays from 8:30 AM - 5:30 PM Arizona time.

It's What Goes On Beneath the Surface of Your Skin That Counts

Normal Healthy Skin Barrier

In normal skin, the skin barrier prevents excess water loss and prevents invasion by micro-organisms/allergens and chemicals

Skin Barrier in Atopic Dermatitis (Eczema)

When the skin barrier is broken down, as it is in diseases such as atopic dermatitis (eczema), there is a reduction in the key lipids of the stratum corneum (ceramide, cholesterol and free fatty acids). This allows for greater loss of moisture and the entry of microbes and allergens.


Moisturizers re-hydrate the skin and contain humectants and occlusives. Humectants like glycerin attract water into the corneocytes. Occlusives like petroleum jelly provide a physical barrier to seal in moisture and prevent water loss. These ingredients provide temporary relief for dry skin but do not correct the underlying problem in the matrix.

Barrier Repair with EpiCeram

In addition to moisturizing the skin with ingredients such as glycerin and petrolatum, EpiCeram replenishes the lipids in the stratum corneum by providing three essential ingredients, ceramide, cholesterol, and free fatty acid in a patented 3:1:1 ratio that mimics the natural level of the stratum corneum. EpiCeram nourishes the skin by replenishing key lipids and accelerates the healing process in atopic dermatitis.

Frequently Asked Questions

EpiCeram Control Release Skin Barrier Emulsion is a unique, prescription only, topical skin-barrier repair product developed for the treatment of atopic dermatitis. EpiCeram contains 3 essential lipids–ceramides, conjugated linoleic acid (CLA), and cholesterol in a physiologically balanced patented 3:1:1 ratio. Uniquely formulated to address skin barrier function, EpiCeram is also steroid-free, fragrance free, non-comedogenic, 1 paraben-free, and propylene glycol-free.

Purified Water, MultiSal™ Neolipids*, Glyceryl Stearate, Squalane, Glycerin, PEG-100 Stearate, Hydroxypropyl Bispalmitamide MEA (Ceramide), Petrolatum, Dimethicone, Phenoxyethanol, Cholesterol, Conjugated Linoleic Acid, Citric Acid, Palmitic Acid, Xanthan Gum, Potassium Hydroxide, Disodium EDTA, Sorbic Acid, Capric Acid.

*Proprietary microencapsulation system for gradual delivery of key ingredients including Ceramide, CLA, Cholesterol and Palmitic Acid (Formulated with E.Cerifera (Candelilla) wax, corn syrup solids, and modified food starch).

EpiCeram Controlled Release Skin Barrier Emulsion is to be used to treat dry skin conditions and to manage and relieve the burning and itching associated with various types of dermatoses, including atopic dermatitis, irritant contact dermatitis, and radiation dermatitis. EpiCeram helps to relieve dry, waxy skin by maintaining a moist wound and skin environment, which is beneficial to the healing process.

EpiCeram nourishes the skin environment to benefit the healing process in patients with Atopic Dermatitis. The unique MultiSal Encapsulation Delivery Technology is based on a unique proprietary system consisting of multi-component microspheres that contain submicron spheres. These submicron spheres are infused with the physiological lipid in an active form. Rubbing the emulsion onto the skin triggers this two-step delivery system. Once the microsphere is broken the submicron spheres gradually deliver the physiological lipids over time. The special microsphere structure stabilizes the lipids from premature oxidation, yielding the product at its highest efficacy.

Administration of EpiCeram involves applying a thin layer to the affected skin two times per day (or as needed) and massaging it gently into the skin. If there are breaks in the skin, the affected area should be covered with a dressing of choice after treatment.

EpiCeram Controlled Release Skin Barrier Emulsion is an atopic dermatitis treatment that aims to assist in the repair of the skin barrier abnormalities in atopic dermatitis. In this way, EpiCeram differs from other products such as corticosteroids and topical immunomodulators because it targets the outside-in model of atopic dermatitis pathophysiology.

EpiCeram can be used on adults and children; there are no age restrictions on the use of EpiCeram Controlled Release Skin Barrier Emulsion.

Yes, EpiCeram can be used on the face and skin folds. There is no age or location restrictions for EpiCeram.

In a prospective, randomized, investigator-blinded, five-center study, investigators randomly assigned 121 pediatric patients with moderate-to-severe atopic dermatitis to receive EpiCeram or fluticasone propionate 0.05% cream. Treatment with EpiCeram Controlled Release Skin Barrier Emulsion reduced clinical disease severity, decreased pruritus, and improved sleep habits both 14 and 28 days after the initiation of therapy. While fluticasone-treated patients experienced more rapid improvement in these parameters at 14 days, by 28 days, both the EpiCeram Controlled Release Skin Barrier Emulsion and fluticasone arms demonstrated similar improvements in SCORAD, pruritus, and sleep habits score.

EpiCeram Controlled Release Skin Barrier Emulsion does not contain a sunscreen and should always be used in conjunction with a sunscreen in sun exposed areas. In radiation dermatitis and/or in conjunction with ongoing radiation therapy apply following radiation therapy. Do not apply within 4 hours prior to radiation therapy. Apply twice daily or as indicated by the radiation therapist. After application, a temporary tingling sensation may occur (10 to 15 minutes). Keep this and similar products out of the reach of children. Follow directions for use. If condition does not improve within 10 to 14 days, consult a physician.

Following the application of EpiCeram a temporary tingling sensation may occur (10-15 minutes).

EpiCeram Controlled Release Skin Barrier Emulsion is available in a 90g tube and a 225g airless pump.

Primus Care Direct is a hassle-free, mail-order pharmacy service where patients can get their EpiCeram prescription for $20, Medicare patients included. This is the lowest possible price available and includes free home delivery. If you have insurance, you may pay even less.

In addition to patient savings and convenience, Primus Care Direct saves time for healthcare practitioners by helping to increase fill rates and eliminating call-backs for prior authorizations.

EpiCeram is also available at retail pharmacies, but Primus Care Direct guarantees patients will pay the lowest possible price on their prescription.