EpiCeram® is the Most Complete Ceramide-Dominant Formulation for Maximum Skin Barrier Repair in Patients with Atopic Dermatitis

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EpiCeram Maintains a Healthy Skin Barrier That Goes Beyond Moisturizing


EpiCeram helps repair and heal the skin barrier through a unique mechanism of action not commonly found in other medications. EpiCeram contains 3 essential lipids– ceramides, conjugated linoleic acid (CLA), and cholesterol — in a physiologically balanced patented 3:1:1 ratio, which are reduced in patients with eczema and atopic dermatitis. EpiCeram is steroid-free, fragrance-free, noncomedogenic, paraben-free, and propylene glycol-free.



Nourishing the Skin Barrier with EpiCeram



EpiCeram with Patented MultiSal™ Technology Allows for High-Lipid Deposition and Enhanced Absorption over Time


The unique MultiSal Encapsulation Delivery Technology is based on a unique proprietary system consisting of multi-component microspheres that contain submicron spheres. These submicron spheres are infused with the physiological lipid in an active form. Rubbing the emulsion onto the skin triggers this two-step delivery system. Once the microsphere is broken, the submicron spheres gradually deliver the physiological lipids over time. The special microsphere structure stabilizes the lipids from premature oxidation.



Before & After Photos




Adult Patient (Age 19, Male)


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After


Adult Patient (Age 58, Female)


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After


Child Patient (Age 14, Male)


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After


Adolescent Patient (Age 17, Male)


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After





Clinical Studies


EpiCeram Compared to Fluticasone (Cultivate®)



In a prospective investigator blinded randomized trial of 121 pediatric patients with moderate-to severe atopic dermatitis, EpiCeram used as monotherapy demonstrated efficacy comparable to a mid-potency topical steroid (fluticasone, Cultivate cream).

Primary outcome measures were:

EpiCeram reduced clinical disease severity, decreased pruritus and improved sleep habits both at the 14 and 28 day assessment points. Although the fluticasone treated group showed significantly greater improvement in SCORAD score at 14 days, EpiCeram did not differ significantly at 28 days. Improvement of pruritus and sleep habit scores were comparable and not statistically significantly different at Day 14 and 28.


SCORAD scores for EpiCeram treated patients decreased 37% and 51% from baseline at 14 and 28 days respectively.


No severe adverse events attributable to these agents occurred in either group. 4 out of 59 patients in the EpiCeram group required “short-term” fluticasone therapy. All four patients were considered rebound flares.


*EpiCeram is not a sleep inducing agent or sleep aid. Reduction in sleep difficulty related to reduction in AD symptoms.

“These results suggest that [EpiCeram] when used as monotherapy can significantly reduce the need for the use of topical steroids for many pediatric patients with moderate-to-severe atopic dermatitis.”
— Jeffrey L. Sugarman MD PhD*

Clinical Study: Open Label Experience Trial


EpiCeram Offers Real World Flexibility in Managing the Common Symptoms of Atopic Dermatitis


In an open-label study of 207 pediatric and adult patients with mild to moderate atopic dermatitis, EpiCeram was applied to affected areas for 3 weeks. Two subjects were also given a prescription for another atopic dermatitis medication and instructed to use this medication along with the EpiCeram as combination therapy, only if their condition worsened.




No serious adverse events were reported. Six subjects reported a total of 7 related, mild or moderate adverse events. An additional nine subjects reported worsening of AD that was considered an AE.

Frequently Asked Questions

EpiCeram Control Release Skin Barrier Emulsion is a unique, prescription only, topical skin-barrier repair product developed for the treatment of atopic dermatitis. EpiCeram contains 3 essential lipids– ceramides, conjugated linoleic acid (CLA), and cholesterol in a physiologically balanced patented 3:1:1 ratio. Uniquely formulated to address skin barrier function, EpiCeram is also steroid-free, fragrance free, non-comedogenic, 1 paraben-free, and propylene glycol-free.

Purified Water, MultiSal™ Neolipids*, Glyceryl Stearate, Squalane, Glycerin, PEG-100 Stearate, Hydroxypropyl Bispalmitamide MEA (Ceramide), Petrolatum, Dimethicone, Phenoxyethanol, Cholesterol, Conjugated Linoleic Acid, Citric Acid, Palmitic Acid, Xanthan Gum, Potassium Hydroxide, Disodium EDTA, Sorbic Acid, Capric Acid.

*Proprietary microencapsulation system for gradual delivery of key ingredients including Ceramide, CLA, Cholesterol and Palmitic Acid (Formulated with E.Cerifera (Candelilla) wax, corn syrup solids, and modified food starch).

EpiCeram Controlled Release Skin Barrier Emulsion is to be used to treat dry skin conditions and to manage and relieve the burning and itching associated with various types of dermatoses, including atopic dermatitis, irritant contact dermatitis, and radiation dermatitis. EpiCeram helps to relieve dry, waxy skin by maintaining a moist wound and skin environment, which is beneficial to the healing process.

EpiCeram nourishes the skin environment to benefit the healing process in patients with Atopic Dermatitis. The unique MultiSal Encapsulation Delivery Technology is based on a unique proprietary system consisting of multi-component microspheres that contain submicron spheres. These submicron spheres are infused with the physiological lipid in an active form. Rubbing the emulsion onto the skin triggers this two-step delivery system. Once the microsphere is broken the submicron spheres gradually deliver the physiological lipids over time. The special microsphere structure stabilizes the lipids from premature oxidation, yielding the product at its highest efficacy.

Administration of EpiCeram involves applying a thin layer to the affected skin two times per day (or as needed) and massaging it gently into the skin. If there are breaks in the skin, the affected area should be covered with a dressing of choice after treatment.

EpiCeram Controlled Release Skin Barrier Emulsion is an atopic dermatitis treatment that aims to assist in the repair of the skin barrier abnormalities in atopic dermatitis. In this way, EpiCeram differs from other products such as corticosteroids and topical immunomodulators because it targets the outside-in model of atopic dermatitis pathophysiology.

EpiCeram can be used on adults and children; there are no age restrictions on the use of EpiCeram Controlled Release Skin Barrier Emulsion.

Yes, EpiCeram can be used on the face and skin folds. There is no age or location restrictions for EpiCeram.

In a prospective, non-controlled study conducted in patients with mild-to-moderate atopic dermatitis, EpiCeram demonstrated symptomatic relief when used in combination with other available therapies, such as corticosteroids and topical immunomodulators, in some patients.

In a prospective, randomized, investigator-blinded, five-center study, investigators randomly assigned 121 pediatric patients with moderate-to-severe atopic dermatitis to receive EpiCeram or fluticasone propionate 0.05% cream. Treatment with EpiCeram Controlled Release Skin Barrier Emulsion reduced clinical disease severity, decreased pruritus, and improved sleep habits both 14 and 28 days after the initiation of therapy. While fluticasone-treated patients experienced more rapid improvement in these parameters at 14 days, by 28 days, both the EpiCeram Controlled Release Skin Barrier Emulsion and fluticasone arms demonstrated similar improvements in SCORAD, pruritus, and sleep habits score.

EpiCeram is contraindicated in persons with known hypersensitivity to any of the components of the formulation.

EpiCeram Controlled Release Skin Barrier Emulsion does not contain a sunscreen and should always be used in conjunction with a sunscreen in sun exposed areas. In radiation dermatitis and/or in conjunction with ongoing radiation therapy apply following radiation therapy. Do not apply within 4 hours prior to radiation therapy. Apply twice daily or as indicated by the radiation therapist. After application, a temporary tingling sensation may occur (10 to 15 minutes). Keep this and similar products out of the reach of children. Follow directions for use. If condition does not improve within 10 to 14 days, consult a physician.

Following the application of EpiCeram a temporary tingling sensation may occur (10-15 minutes).

EpiCeram Controlled Release Skin Barrier Emulsion is available in a 90g tube and a 225g airless pump.

Primus Care Direct is a hassle-free, mail-order pharmacy service where patients can get their EpiCeram prescription for $20, Medicare patients included. This is the lowest possible price available and includes free home delivery. If you have insurance, you may pay even less.

In addition to patient savings and convenience, Primus Care Direct saves time for healthcare practitioners by helping to increase fill rates and eliminating call-backs for prior authorizations.

EpiCeram is also available at retail pharmacies, but Primus Care Direct guarantees patients will pay the lowest possible price on their prescription.

Practitioner Resources

Find more resources and clinical support for EpiCeram.